{"id":272018,"date":"2024-07-12T11:07:53","date_gmt":"2024-07-12T09:07:53","guid":{"rendered":"https:\/\/www.matachana.com\/?p=272018"},"modified":"2026-03-25T08:21:46","modified_gmt":"2026-03-25T07:21:46","slug":"retraitement-des-dispositifs-de-laparoscopie-par-sterilisation-a-basse-temperaturevh2o2-ou-ltsf","status":"publish","type":"post","link":"https:\/\/www.matachana.com\/fr\/retraitement-des-dispositifs-de-laparoscopie-par-sterilisation-a-basse-temperaturevh2o2-ou-ltsf\/","title":{"rendered":"RETRAITEMENT DES DISPOSITIFS DE LAPAROSCOPIE PAR  ST\u00c9RILISATION \u00c0 BASSE TEMP\u00c9RATURE\u2026VH2O2 ou LTSF ?"},"content":{"rendered":"<h3>Comparaison en termes d&#8217;agressivit\u00e9 et de facilit\u00e9 d&#8217;utilisation avec des dispositifs m\u00e9dicaux<\/h3>\n<p>&nbsp;<\/p>\n<hr size=\"2px\" \/>\n<p><strong>Auteurs :<\/strong><\/p>\n<p>Dr. Daniel V\u00e1zquez<strong><sup>1<\/sup><\/strong>; Dr. Nelson Carreras<strong><sup>2<\/sup><\/strong>; Dr. Alex Zamora<strong><sup>3<\/sup><\/strong>; Ing. Alejandro Ram\u00edrez<strong><sup>4<\/sup><\/strong>. <strong><sup>1<\/sup><\/strong>Matachana Test Center Coordinator, <strong><sup>2<\/sup><\/strong>Global Product Manager Consumables, <strong><sup>3<\/sup><\/strong>RDI Chemist,<sup> <strong>4<\/strong><\/sup>Global Product Manager Low Temperature Sterilizers.<\/p>\n<p><strong>Abr\u00e9viations :<\/strong><\/p>\n<p>VH2O2 \u2013 Peroxyde d&#8217;Hydrog\u00e8ne Vaporis\u00e9, LTSF \u2013 Vapeur \u00e0 Basse Temp\u00e9rature et Formald\u00e9hyde, DMR \u2013 Dispositif M\u00e9dical Retraitable, PCD \u2013 Dispositif d&#8217;\u00c9preuve de Proc\u00e9d\u00e9<\/p>\n<hr size=\"2px\" \/>\n<h2>\u00a0<\/h2>\n<h3><strong>RECOMMANDATIONS DE LA WFHSS<\/strong><\/h3>\n<p>Selon les recommandations de la WFHSS \u00ab\u00a0<em>les DMR thermosensibles requi\u00e8rent une s\u00e9rie de cycles adapt\u00e9s \u00e0 leurs sp\u00e9cificit\u00e9s mat\u00e9rielles et g\u00e9om\u00e9triques. Certains instruments de chirurgie mini-invasive thermocompatibles sont sujets \u00e0 un vieillissement acc\u00e9l\u00e9r\u00e9 (par exemple, les dispositifs de laparoscopie). Certains pays offrent la possibilit\u00e9 d&#8217;utiliser la st\u00e9rilisation \u00e0 basse temp\u00e9rature, d&#8217;autres non\u00a0\u00bb. <\/em><strong><sup>[1]<\/sup><\/strong><\/p>\n<table style=\"border: hidden;\">\n<tbody style=\"border: hidden; background-color: rgba(242,243,244,1.00);\">\n<tr style=\"border: hidden;\">\n<td style=\"border: hidden; text-align: justify;\">MAIS SI NOUS CHOISISSONS DE ST\u00c9RILISER LES DISPOSITIFS DE LAPAROSCOPIE \u00c0 L&#8217;AIDE D&#8217;UNE M\u00c9THODE \u00c0 BASSE TEMP\u00c9RATURE, QUELLE EST LA TECHNOLOGIE LA MOINS AGRESSIVE POUR LES DISPOSITIFS M\u00c9DICAUX ? VH2O2 OU LTSF ?<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>\u00a0<\/h2>\n<h3><strong>L&#8217;EFFET DU FORMALD\u00c9HYDE SUR LES PROT\u00c9INES MICROBIENNES<\/strong><\/h3>\n<p>En solution, le formald\u00e9hyde peut se pr\u00e9senter sous diff\u00e9rentes formes, li\u00e9es \u00e0 des mol\u00e9cules d&#8217;eau. On trouve dans la solution de formald\u00e9hyde des esp\u00e8ces monom\u00e9riques (monohydrat\u00e9es) appel\u00e9es <strong>m\u00e9thyl\u00e8ne glycols <\/strong>et des esp\u00e8ces polym\u00e9riques (polyhydrat\u00e9es) appel\u00e9es <strong>polyoxym\u00e9thyl\u00e8ne glycols<\/strong>. \u00c0 temp\u00e9rature ambiante et \u00e0 faible concentration, le rapport monom\u00e8re\/polym\u00e8re de la solution est de 1:1200, conform\u00e9ment aux donn\u00e9es de diverses \u00e9tudes.<strong><sup>[2-6]<\/sup><\/strong><\/p>\n<p>En outre, les polyoxym\u00e9thyl\u00e8nes peuvent comporter un nombre variable de groupes glycol\u00a0:<\/p>\n<ul>\n<li>CH<sub>2<\/sub>O &#8211; formald\u00e9hyde<\/li>\n<li>CH<sub>2<\/sub>(OH)<sub>2<\/sub> &#8211; m\u00e9thyl\u00e8ne glycol, form\u00e9 par l&#8217;ajout d&#8217;une mol\u00e9cule d&#8217;eau<\/li>\n<li>(CH<sub>2<\/sub>O)<sub>3<\/sub> &#8211; trioxym\u00e9thyl\u00e8ne glycol ou paraformald\u00e9hyde<\/li>\n<li>(CH<sub>2<\/sub>O)<sub>n<\/sub> &#8211; diff\u00e9rents polyoxym\u00e9thyl\u00e8ne glycols<\/li>\n<\/ul>\n<p>Ces esp\u00e8ces polym\u00e9riques peuvent se polym\u00e9riser pour former un pr\u00e9cipit\u00e9 blanc en fonction de la temp\u00e9rature et de la concentration. Dans la solution <em>e-bag<\/em><sup>\u00ae<\/sup>, l&#8217;\u00e9thanol permet de stabiliser le formald\u00e9hyde et d&#8217;emp\u00eacher sa polym\u00e9risation, \u00e9vitant ainsi la formation de pr\u00e9cipit\u00e9s.<strong><sup>[7-9]<\/sup><\/strong><\/p>\n<p>Le formald\u00e9hyde est stable \u00e0 l&#8217;\u00e9tat gazeux et son activit\u00e9 biocide provient de sa capacit\u00e9 \u00e0 interagir avec les groupes amin\u00e9s des prot\u00e9ines et des acides nucl\u00e9iques, comme l&#8217;illustre la Figure\u00a01. Son groupe carboxyle est tr\u00e8s r\u00e9actif et interagit avec les prot\u00e9ines et les acides nucl\u00e9iques, ce qui lui conf\u00e8re une efficacit\u00e9 \u00e0 large spectre contre les micro-organismes.<strong><sup>[10]<\/sup><\/strong><\/p>\n<h4><strong>M\u00e9canisme microbicide :<\/strong><\/h4>\n<p>Le groupe ald\u00e9hyde du formald\u00e9hyde r\u00e9ticule les prot\u00e9ines membranaires, les <strong>d\u00e9naturant<\/strong>, et endommage \u00e9galement l&#8217;ADN et l&#8217;ARN, perturbant les fonctions cellulaires et entra\u00eenant la mort des micro-organismes. <strong><sup>[11\u201112]<\/sup><\/strong><\/p>\n<p><img decoding=\"async\" src=\"https:\/\/www.matachana.com\/wp-content\/uploads\/2024\/07\/MATACHANA_BLOG_Instrumental_LAPAROSCOPIO_03.jpg\" width=\"1000\" \/><\/p>\n<p><strong>Figure 1.<\/strong> R\u00e9ticulation et formation de ponts m\u00e9thyl\u00e8ne par le formald\u00e9hyde entre\u00a0(A)\u00a0prot\u00e9ines et\u00a0(B)\u00a0prot\u00e9ines et acides nucl\u00e9iques.<sup> [17]<\/sup><\/p>\n<h3><strong>L&#8217;EFFET DU VH2O2 CONTRE LES MICRO-ORGANISMES<\/strong><\/h3>\n<p>Le Peroxyde d&#8217;Hydrog\u00e8ne Vaporis\u00e9 (VH2O2) est une substance hautement oxydante et ses d\u00e9riv\u00e9s actifs produits apr\u00e8s d\u00e9composition ont de puissants effets d&#8217;oxydation qui perturbent directement les cytomembranes cellulaires des micro-organismes. Cependant, cette puissante action oxydante peut \u00e9galement avoir un impact sur les mat\u00e9riaux utilis\u00e9s dans les dispositifs m\u00e9dicaux, entra\u00eenant potentiellement des probl\u00e8mes tels que la corrosion ou la d\u00e9gradation progressive des mat\u00e9riaux au fil du temps. <strong><sup>[13]<\/sup><\/strong><\/p>\n<table style=\"border: hidden;\">\n<tbody style=\"border: hidden; background-color: rgba(242,243,244,1.00);\">\n<tr style=\"border: hidden;\">\n<td style=\"border: hidden; text-align: justify;\">NOUS AVONS VU QUE LE LTSF EST LA TECHNOLOGIE LA MOINS AGRESSIVE, MAIS QUELLE EST LA TECHNOLOGIE LA PLUS FACILE \u00c0 UTILISER ?<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>Le chargement du st\u00e9rilisateur est une \u00e9tape cruciale du processus de st\u00e9rilisation terminale. Apr\u00e8s avoir lav\u00e9, inspect\u00e9, assembl\u00e9 (si n\u00e9cessaire), s\u00e9ch\u00e9 et emball\u00e9 les dispositifs laparoscopiques, nous devons charger correctement le st\u00e9rilisateur conform\u00e9ment aux sp\u00e9cifications du programme de st\u00e9rilisation s\u00e9lectionn\u00e9. Un processus de chargement correct, conforme au mode d&#8217;emploi du st\u00e9rilisateur, garantira que les conditions de st\u00e9rilisation de la charge seront respect\u00e9es apr\u00e8s la s\u00e9lection du programme de st\u00e9rilisation li\u00e9 \u00e0 la charge.<\/p>\n<p>\u00c0 cet \u00e9gard, les st\u00e9rilisateurs VH2O2 sont connus pour leur complexit\u00e9 au cours du processus de chargement. En g\u00e9n\u00e9ral, la <strong>longueur maximale<\/strong> et le <strong>diam\u00e8tre interne minimal <\/strong>de chaque DMR, ainsi que le <strong>nombre total de dispositifs avec lumi\u00e8re<\/strong> doivent \u00eatre v\u00e9rifi\u00e9s.<strong><sup>[14-16]<\/sup><\/strong> Mais pas seulement, comme dans toutes les modalit\u00e9s de st\u00e9rilisation terminale, le <strong>poids total de la charge<\/strong> doit \u00e9galement \u00eatre contr\u00f4l\u00e9.<strong><sup>[14-16]<\/sup><\/strong> Les diff\u00e9rentes combinaisons de ces exigences de chargement jouent un r\u00f4le crucial dans la st\u00e9rilisation. En effet, si l&#8217;une d&#8217;entre elles n&#8217;est pas respect\u00e9e, la charge compl\u00e8te ne sera pas garantie comme \u00e9tant st\u00e9rilis\u00e9e. Il s&#8217;agit d&#8217;un facteur de stress suppl\u00e9mentaire pour le personnel de la centrale de st\u00e9rilisation.<\/p>\n<h3><strong>LA FACILIT\u00c9 DU CHARGEMENT &#8211; Vapeur \u00e0 Basse Temp\u00e9rature et Formald\u00e9hyde<\/strong><\/h3>\n<p>D&#8217;autre part, la technologie de la <strong>Vapeur \u00e0 Basse Temp\u00e9rature et Formald\u00e9hyde <\/strong>offre d&#8217;excellentes performances en mati\u00e8re de p\u00e9n\u00e9trabilit\u00e9, gr\u00e2ce \u00e0 l&#8217;utilisation de la vapeur pour transporter l&#8217;agent st\u00e9rilisant dans les lumi\u00e8res \u00e9troites et \u00e0 la grande stabilit\u00e9 de la mol\u00e9cule de formald\u00e9hyde. Cette technologie exige par cons\u00e9quent des sp\u00e9cifications de chargement simples\u00a0: seul <strong>le poids total de la charge<\/strong> doit \u00eatre confirm\u00e9.<\/p>\n<p>Le tableau suivant pr\u00e9sente les r\u00e9sultats des tests de p\u00e9n\u00e9trabilit\u00e9 effectu\u00e9s par Matachana Test Center \u00e0l&#8217;aide d&#8217;indicateurs biologiques \u00e0 l&#8217;int\u00e9rieur d&#8217;un r\u00e9cipient de type PCD de diff\u00e9rentes longueurs etdiam\u00e8tres int\u00e9rieurs. Dans le cas du proc\u00e9d\u00e9 LTSF, les indicateurs biologiques utilis\u00e9s sont conformes auxexigences de la norme ISO 11138-5. Pour les essais avec du peroxyde d&#8217;hydrog\u00e8ne, des indicateursbiologiques \u00e0 base de spores de Geobacillus stearothermophilus ont \u00e9t\u00e9 utilis\u00e9s, dont la caract\u00e9risation dela r\u00e9sistance a \u00e9t\u00e9 r\u00e9alis\u00e9e en suspension liquide, une approche qui permet de d\u00e9terminer de mani\u00e8rereproductible les param\u00e8tres de r\u00e9sistance microbiologique de l&#8217;indicateur biologique, comme d\u00e9crit dansla bibliographie sp\u00e9cialis\u00e9e<strong><sup>[18]<\/sup><\/strong><\/p>\n<p>Dans ce cas, les exigences g\u00e9n\u00e9rales \u00e9tablies dans la norme UNE-EN ISO 11138-1 s&#8217;appliquent.<\/p>\n<p><strong>Tableau\u00a01.<\/strong> Comparaison de l&#8217;efficacit\u00e9 de la st\u00e9rilisation entre les technologies VH2O2 et LTSF en lumen de l&#8217;acier inoxydable.<\/p>\n<table style=\"border-color: #FFFFFF;\" align=\"center\">\n<tbody>\n<tr style=\"border-color: #FFFFFF; background-color: #1b365d;\">\n<td style=\"border-color: #FFFFFF; background-color: #1b365d;\" align=\"center\" width=\"100px\"><span style=\"color: rgba(255,255,255,1.00);\">\uf0c6 <strong>Int\u00e9rieur<\/strong><br \/>[mm]<\/span><\/td>\n<td style=\"border-color: #FFFFFF; background-color: #1b365d;\" align=\"center\" width=\"100px\"><span style=\"color: rgba(255,255,255,1.00);\"><strong>Longueur<\/strong><br \/>[mm]<\/span><\/td>\n<td style=\"border-color: #FFFFFF; background-color: #1b365d;\" align=\"center\" width=\"250px\"><span style=\"color: rgba(255,255,255,1.00);\">St\u00e9rilisation LTSF<br \/>Correct \/ Incorrect<\/span><\/td>\n<td style=\"border-color: #FFFFFF; background-color: #1b365d;\" align=\"center\" width=\"250px\"><span style=\"color: rgba(255,255,255,1.00);\">St\u00e9rilisation VH2O2<br \/>Correct\/Incorrect<\/span><\/td>\n<\/tr>\n<tr style=\"border-color: #FFFFFF;\">\n<td style=\"border-color: #FFFFFF; background-color: #eeeeee;\" rowspan=\"2\" align=\"center\"><span style=\"color: gray;\">0,5<\/span><\/td>\n<td style=\"border-color: #FFFFFF; background-color: #eeeeee;\" align=\"center\"><span style=\"color: gray;\">500<\/span><\/td>\n<td style=\"border-color: #FFFFFF; background-color: #86e378;\" align=\"center\"><span style=\"color: rgba(255,255,255,1.00);\">Correct<\/span><\/td>\n<td style=\"border-color: #FFFFFF; background-color: #f48082;\" align=\"center\"><span style=\"color: rgba(255,255,255,1.00);\">Incorrect<\/span><\/td>\n<\/tr>\n<tr style=\"border-color: #FFFFFF;\">\n<td style=\"border-color: #FFFFFF; background-color: #eeeeee;\" align=\"center\"><span style=\"color: gray;\">1000<\/span><\/td>\n<td style=\"border-color: #FFFFFF; background-color: #f48082;\" align=\"center\"><span style=\"color: rgba(255,255,255,1.00);\">Incorrect<\/span><\/td>\n<td style=\"border-color: #FFFFFF; background-color: #f48082;\" align=\"center\"><span style=\"color: rgba(255,255,255,1.00);\">Incorrect<\/span><\/td>\n<\/tr>\n<tr style=\"border-color: #FFFFFF;\">\n<td style=\"border-color: #FFFFFF; background-color: #eeeeee;\" rowspan=\"3\" align=\"center\"><span style=\"color: gray;\">0,7<\/span><\/td>\n<td style=\"border-color: #FFFFFF; background-color: #eeeeee;\" align=\"center\"><span style=\"color: gray;\">500<\/span><\/td>\n<td style=\"border-color: #FFFFFF; background-color: #86e378;\" align=\"center\"><span style=\"color: rgba(255,255,255,1.00);\">Correct<\/span><\/td>\n<td style=\"border-color: #FFFFFF; background-color: #86e378;\" align=\"center\"><span style=\"color: rgba(255,255,255,1.00);\">Correct<\/span><\/td>\n<\/tr>\n<tr style=\"border-color: #FFFFFF;\">\n<td style=\"border-color: #FFFFFF; background-color: #eeeeee;\" align=\"center\"><span style=\"color: gray;\">1000<\/span><\/td>\n<td style=\"border-color: #FFFFFF; background-color: #86e378;\" align=\"center\"><span style=\"color: rgba(255,255,255,1.00);\">Correct<\/span><\/td>\n<td style=\"border-color: #FFFFFF; background-color: #86e378;\" align=\"center\"><span style=\"color: rgba(255,255,255,1.00);\">Correct<\/span><\/td>\n<\/tr>\n<tr style=\"border-color: #FFFFFF;\">\n<td style=\"border-color: #FFFFFF; background-color: #eeeeee;\" align=\"center\"><span style=\"color: gray;\">2000<\/span><\/td>\n<td style=\"border-color: #FFFFFF; background-color: #86e378;\" align=\"center\"><span style=\"color: rgba(255,255,255,1.00);\">Correct<\/span><\/td>\n<td style=\"border-color: #FFFFFF; background-color: #f48082;\" align=\"center\"><span style=\"color: rgba(255,255,255,1.00);\">Incorrect<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>Le <strong>tableau\u00a01<\/strong> confirme une plus haute performance de p\u00e9n\u00e9trabilit\u00e9 par rapport aux st\u00e9rilisateurs\u00a0VH2O2, qui ne sont g\u00e9n\u00e9ralement pas compatibles avec les lumens rigides d&#8217;un diam\u00e8tre int\u00e9rieur inf\u00e9rieur \u00e0 0,7\u00a0mm et d&#8217;une longueur sup\u00e9rieure \u00e0 500\u00a0mm. <strong><sup>[14] <\/sup><\/strong>Quoi qu&#8217;il en soit, certains fabricants<strong><sup>[16]<\/sup><\/strong> indiquent un diam\u00e8tre int\u00e9rieur de 0,48\u00a0mm et une longueur ne d\u00e9passant pas 100\u00a0mm, mais en limitant toujours le nombre de lumens \u00e0\u00a020.<\/p>\n<h2>\u00a0<\/h2>\n<h3><strong>CONCLUSIONS<\/strong><\/h3>\n<p>En conclusion, le processus de st\u00e9rilisation LTSF est moins agressif pour les mat\u00e9riaux que les autres technologies de st\u00e9rilisation \u00e0 basse temp\u00e9rature, car son effet microbicide, qui repose sur la d\u00e9naturation des prot\u00e9ines plut\u00f4t que sur l&#8217;oxydation, minimise les dommages caus\u00e9s aux mat\u00e9riaux.<\/p>\n<ul>\n<li><strong>Efficacit\u00e9 de la st\u00e9rilisation\u00a0:<\/strong> le LTSF et le VH2O2 offrent tous deux une grande efficacit\u00e9 de st\u00e9rilisation, mais leurs m\u00e9canismes diff\u00e8rent de mani\u00e8re significative.<\/li>\n<\/ul>\n<ul>\n<li><strong>Compatibilit\u00e9 des mat\u00e9riaux\u00a0:<\/strong> le LTSF se distingue par son traitement non agressif pour les mat\u00e9riaux, en particulier des instruments plus sensibles, gr\u00e2ce \u00e0 ses m\u00e9canismes de <strong>d\u00e9naturation des prot\u00e9ines<\/strong>, ce qui contraste avec l&#8217;impact oxydatif potentiel \u00e0 long terme du\u00a0VH2O2 sur les mat\u00e9riaux.<\/li>\n<\/ul>\n<ul>\n<li><strong>Facilit\u00e9 d&#8217;utilisation\u00a0:<\/strong> la technologie LTSF pr\u00e9sente une simplicit\u00e9 d&#8217;utilisation\u00a0: il suffit en effet de respecter les exigences en mati\u00e8re de <strong>poids total <\/strong>pendant le processus de chargement.<\/li>\n<\/ul>\n<p>Le choix entre ces deux technologies d\u00e9pend de facteurs tels que les mat\u00e9riaux des dispositifs, les protocoles de la centrale de st\u00e9rilisation et la conformit\u00e9 r\u00e9glementaire. La compr\u00e9hension de ces nuances garantit des r\u00e9sultats de st\u00e9rilisation optimaux tout en pr\u00e9servant l&#8217;int\u00e9grit\u00e9 des instruments m\u00e9dicaux.<\/p>\n<hr size=\"2px\" \/>\n<h3>BIBLIOGRAPHIE<\/h3>\n<p><strong><sup>1<\/sup><\/strong> <em>Reusable medical device \u2013 Wfhss Guidelines<\/em>. (n.d.). Retrieved June 20, 2024, from <a href=\"https:\/\/wfhss-guidelines.com\/reusable-medical-device\/\">https:\/\/wfhss-guidelines.com\/reusable-medical-device\/<\/a><\/p>\n<p><strong><sup>2<\/sup><\/strong> Rivlin, M., Eliav, U., &amp; Navon, G. (2015). NMR studies of the equilibria and reaction rates in aqueous solutions of formaldehyde. <em>Journal of Physical Chemistry B<\/em>, <em>119<\/em>(12), 4479\u20134487. <a href=\"https:\/\/doi.org\/10.1021\/JP513020Y\">https:\/\/doi.org\/10.1021\/JP513020Y<\/a><\/p>\n<p><strong><sup>3<\/sup><\/strong> Gold, A., Utterback, D. F., &amp; Millington, D. S. (1984). Quantitative Analysis of Gas-Phase Formaldehyde Molecular Species at Equilibrium with Formalin Solution. <em>Analytical Chemistry<\/em>, <em>56<\/em>(14), 2879\u20132882. <a href=\"https:\/\/doi.org\/10.1021\/AC00278A058\">https:\/\/doi.org\/10.1021\/AC00278A058<\/a><\/p>\n<p><strong><sup>4 <\/sup><\/strong>Winkelman, J. G. M., Ottens, M., &amp; Beenackers, A. A. C. M. (2000). The kinetics of the dehydration of methylene glycol. In <em>Chemical Engineering Science<\/em> (Vol. 55, Issue 11). PERGAMON-ELSEVIER SCIENCE LTD. <a href=\"https:\/\/research.rug.nl\/en\/publications\/the-kinetics-of-the-dehydration-of-methylene-glycol\">https:\/\/research.rug.nl\/en\/publications\/the-kinetics-of-the-dehydration-of-methylene-glycol<\/a><\/p>\n<p><strong><sup>5<\/sup><\/strong> Winkelman, J. G. M., Voorwinde, O. K., Ottens, M., Beenackers, A. A. C. M., &amp; Janssen, L. P. B. M. (2002). Kinetics and chemical equilibrium of the hydration of formaldehyde. <em>Chemical Engineering Science<\/em>, <em>57<\/em>(19), 4067\u20134076. <a href=\"https:\/\/doi.org\/10.1016\/S0009-2509(02)00358-5\">https:\/\/doi.org\/10.1016\/S0009-2509(02)00358-5<\/a><\/p>\n<p><strong><sup>6<\/sup><\/strong> Matubayasi, N., Morooka, S., Nakahara, M., &amp; Takahashi, H. (2007). Chemical equilibrium of formaldehyde and methanediol in hot water: Free-energy analysis of the solvent effect. <em>Journal of Molecular Liquids<\/em>, <em>134<\/em>(1\u20133), 58\u201363. <a href=\"https:\/\/doi.org\/10.1016\/J.MOLLIQ.2006.12.002\">https:\/\/doi.org\/10.1016\/J.MOLLIQ.2006.12.002<\/a><\/p>\n<p><strong><sup>7<\/sup><\/strong> Kent, D. R., Widicus, S. L., Blake, G. A., Goddard, W. A., &amp; Iii, W. A. G. (2003). A theoretical study of the conversion of gas phase methanediol to formaldehyde \ue904 A theoretical study of the conversion of gas phase methanediol to formaldehyde. <em>J. Chem. Phys<\/em>, <em>119<\/em>, 5117\u20135120. https:\/\/doi.org\/10.1063\/1.1596392<\/p>\n<p><sup>\u00a0<\/sup><strong><sup>8 <\/sup><\/strong>Kleimeier, C. F., Turner, N. F., Singh, A. M., Fortenberry, S. K., &amp; Kaiser, R. C. (2022). Synthesis of methanediol [CH 2 (Oh) 2 ]: The simplest geminal diol. <em>Proceedings of the National Academy of Sciences<\/em>, <em>119<\/em>(1), 2111938119. <a href=\"https:\/\/doi.org\/10.1073\/pnas.2111938119\">https:\/\/doi.org\/10.1073\/pnas.2111938119<\/a><\/p>\n<p><strong><sup>9 <\/sup><\/strong>Lilienblum, W. (2012). <em>Opinion of the Scientific Committee on Consumer Safety on methylene glycol; Opinion of the Scientific Committee on Consumer Safety on methylene glycol<\/em>. https:\/\/doi.org\/10.2772\/83316<\/p>\n<p><strong><sup>10 <\/sup><\/strong>World Health Organization. (2016). <em>Decontamination and Reprocessing of Medical Devices for Health-care Facilities<\/em>. <a href=\"https:\/\/iris.who.int\/bitstream\/handle\/10665\/250232\/9789241549851-eng.pdf;jsessionid=3D2B2C5446E0235F3AEEE6006D7EBA16?sequence=1\">http:\/\/www.who.int<\/a><\/p>\n<p><strong><sup>11<\/sup><\/strong> Mcdonnell, G., Russell, A. D., Operations, L., &amp; Louis, S. (1999). Antiseptics and Disinfectants: Activity, Action, and Resistance. <em>CLINICAL MICROBIOLOGY REVIEWS<\/em>, <em>12<\/em>(1), 147\u2013179.<\/p>\n<p><strong><sup>12<\/sup><\/strong> Loshon, C. A., Genest, P. C., Setlow, B., &amp; Setlow, P. (1999). Formaldehyde kills spores of Bacillus subtilis by DNA damage and small, acid-soluble spore proteins of the alpha\/beta-type protect spores against this DNA damage. <em>Journal of Applied Microbiology<\/em>, <em>87<\/em>(1), 8\u201314. <a href=\"https:\/\/doi.org\/10.1046\/J.1365-2672.1999.00783.X\">https:\/\/doi.org\/10.1046\/J.1365-2672.1999.00783.X<\/a><\/p>\n<p><strong><sup>13<\/sup><\/strong> Tao, M., Ao, T., Mao, X., Yan, X., Javed, R., Hou, W., Wang, Y., Sun, C., Lin, S., Yu, T., &amp; Ao, Q. (2021). Sterilization and disinfection methods for decellularized matrix materials: Review, consideration and proposal. <em>Bioactive Materials<\/em>, <em>6<\/em>(9), 2927. <a href=\"https:\/\/doi.org\/10.1016\/J.BIOACTMAT.2021.02.010\">https:\/\/doi.org\/10.1016\/J.BIOACTMAT.2021.02.010<\/a><\/p>\n<p><strong><sup>14<\/sup><\/strong> STERRAD User\u2019s Guide REF A11150401. ASP. Retrieved June 20, 2024, from <a href=\"https:\/\/eifu.asp.com\/\">https:\/\/eifu.asp.com\/<\/a><\/p>\n<p><strong><sup>15<\/sup><\/strong> STERRADTM Low temperature sterilization. ASP. Retrieved June 20, 2024, from <a href=\"https:\/\/www.asp.com\/low-temp-esterilization\">https:\/\/www.asp.com\/low-temp-esterilization<\/a><\/p>\n<p><strong><sup>16<\/sup><\/strong> STERIS <em>Instructions For Use | Operator Manual. <\/em>STERIS. EN 10085896 Revision H. Retrieved June 20, 2024, from <a href=\"https:\/\/www.steris.com\/healthcare\/instructions-for-use\">https:\/\/www.steris.com\/healthcare\/instructions-for-use<\/a><\/p>\n<p><strong><sup>17<\/sup><\/strong> Adapted from \u201cKouchmeshky, A., &amp; McCaffery, P. (2020). Use of fixatives for immunohistochemistry and their application for detection of retinoic acid synthesizing enzymes in the central nervous system. <em>Methods in Enzymology<\/em>, 637, 119\u2013150. <a href=\"https:\/\/doi.org\/10.1016\/BS.MIE.2020.03.010\">https:\/\/doi.org\/10.1016\/BS.MIE.2020.03.010<\/a>\u201d with <a href=\"http:\/\/www.biorender.com\/\">BioRender.com <\/a><\/p>\n<p><strong><sup>18<\/sup><\/strong> Deinhard, B., Hartmann, B., &#038; Heeg, P. (2015). Resistance of <em>Geobacillus stearothermophilus<\/em> spores used in biological indicators for hydrogen peroxide sterilization processes. <em>Journal of Hospital Infection<\/em>, 91(3), 234\u2013240.<\/p>\n<p>\n  <a href=\"https:\/\/matachanagroup.box.com\/s\/kgorcglo0hrrrjauguigx3j8e4akowxf\" target=\"_blank\" rel=\"noopener noreferrer\"><br \/>\n    <img decoding=\"async\" src=\"https:\/\/www.matachana.com\/wp-content\/uploads\/2024\/07\/ICO_Descarga_PDF_fr.png\" width=\"250\" \/><br \/>\n  <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Comparaison en termes d&#8217;agressivit\u00e9 et de facilit\u00e9 d&#8217;utilisation avec des dispositifs m\u00e9dicaux &nbsp; Auteurs : Dr. Daniel V\u00e1zquez1; Dr. Nelson Carreras2; Dr. Alex Zamora3; Ing. Alejandro Ram\u00edrez4. 1Matachana Test Center Coordinator, 2Global Product Manager Consumables, 3RDI Chemist, 4Global Product Manager Low Temperature Sterilizers. Abr\u00e9viations : VH2O2 \u2013 Peroxyde d&#8217;Hydrog\u00e8ne Vaporis\u00e9, LTSF \u2013 Vapeur \u00e0 Basse [&hellip;]<\/p>\n","protected":false},"author":13,"featured_media":272013,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","inline_featured_image":false},"categories":[183],"tags":[],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v20.6 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>MATACHANA - RETRAITEMENT DISPOSITIFS LAPAROSCOPIE<\/title>\n<meta name=\"description\" content=\"RETRAITEMENT DES DISPOSITIFS DE LAPAROSCOPIE PAR ST\u00c9RILISATION \u00c0 BASSE TEMP\u00c9RATURE\u2026VH2O2 ou LTSF ?\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.matachana.com\/fr\/retraitement-des-dispositifs-de-laparoscopie-par-sterilisation-a-basse-temperaturevh2o2-ou-ltsf\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"MATACHANA - 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